Search Result

Search Results for " complement c3 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP2180L	Compstatin control peptide acetate		Complement System
	Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.		Complement System
T9695L	POT-4 acetate	POT-4 acetate (934461-40-2 free base)	Complement System
	POT-4 acetate inhibits Complement C3 activation. POT-4 acetate can be used for studies about age-related macular degeneration.		Complement System
TP2139	AMY-101	Cp40	Others
	AMY-101 is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.		Others
T75775	Compstatin TFA
	Compstatin TFA, a potent inhibitor of the complement system C3 characterized by species specificity, is a 13-residue cyclic peptide. It selectively binds to baboon C3 and demonstrates resistance to proteolytic cleavage i...
TP2139L	AMY-101 TFA	Cp40 TFA	Others
	AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper in...		Others
T76210	POT-4 TFA
	POT-4 TFA (AL-78898A TFA), a derivative of Compstatin, effectively inhibits the activation of complement factor C3. This compound is utilized in research related to age-related macular degeneration [1] [2].
T64692	AMY-101 acetate
	Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe...
T82474	Empasiprubart	ARGX-117
	Empasiprubart (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. It inhibits the formation of C3 proconvertase, obstructing classical and lectin pathway activation by binding to the Sushi-2...
T77089	Mirococept
	Mirococept (APT070), an antibody designed to target the complement system components C3b/C4b and act as a membrane-localizing C3 convertase inhibitor, effectively diminishes the release of C-peptide and pro-inflammatory ...

Compounds

Compstatin control peptide acetate

TP2180L

Synonym:

Target: Complement System

POT-4 acetate

T9695L

Synonym: POT-4 acetate (934461-40-2 free base)

Target: Complement System

Cat No.	Product Name	Synonyms	Targets
T40646	Lipoteichoic acid		Complement System
	Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.		Complement System

Natural Products

Lipoteichoic acid

T40646

Synonym:

Target: Complement System

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02604	Complement C3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession number is P01027.
TMPH-00231	Complement C3 Protein, Bovine, Recombinant (His & SUMO)	Bovine	E. coli
	Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.5 kDa and the accession number is Q2UVX4.
TMPY-05731	Complement C3 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.43 kDa and the accession number is P01024.
TMPY-05732	Complement C3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.40 kDa and the accession number is XP_005587776.1.
TMPY-06767	Complement C3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.34 kDa and the accession number is NP_033908.2.
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to fo...
TMPK-01268	Complement C2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to health...
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convert...
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement a...
TMPH-02605	Complement C4-B Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of imm...
TMPH-01131	Complement C4-B Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc)	Rat	HEK293 Cells
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPK-00755	Complement Factor D/CFD Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPK-00671	Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPK-00151	Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli sugge...
TMPH-03272	Complement factor D Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classi...
TMPH-02845	Properdin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPH-02844	Properdin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Comple...
TMPH-02921	SUSD4 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classic...
TMPJ-00809	CFH Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal ...
TMPH-03578	SCIN Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a ...
TMPH-03326	MASP2 Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the ...
TMPY-03969	SUSD4 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and ...
TMPH-03665	Vaccinia virus (strain Copenhagen) OPG185 Protein (His)	VACV	E. coli
	Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superin...
TMPH-00534	Gelatinase Protein, Enterococcus faecalis, Recombinant (His & SUMO)	Enterococcus faecalis	E. coli
	Metalloprotease capable of the hydrolysis of insoluble hydrophobic substrates. Hydrolyzes azocoll and gelatin and, at a lower rate, soluble and insoluble collagens. Does not cleave short synthetic peptides. Preferentiall...